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The scientists tested three aspects of behavior -- the ability to learn which part of a maze to negotiate in order to avoid exposure to a bright light or sound; anxiety, which was reflected by time spent exploring the maze’s open areas, and general locomotion.The drunken mice learned significantly less well than the sober ones in trying to avoid the frightening bright light or loud noise.
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The doses of caffeine given to the mice were the equivalent of one to six or eight cups of coffee for humans.
When caffeine and alcohol were given together, the alcohol blocked caffeine’s ability to make the mice more anxious, but caffeine failed to reverse the negative effects that alcohol has on learning, according to Gould and Gulick.
He and colleague Danielle Gulick, Ph D, now of Dartmouth College, gave groups of young adult mice various doses of alcohol and caffeine by injection prior to learning a maze.
A comparison group of mice was given only saline solution.
“The myth about coffee’s sobering powers is particularly important to debunk because the co-use of caffeine and alcohol could actually lead to poor decisions with disastrous outcomes,” Thomas Gould, Ph D, of Temple University and one of the study authors, says in a news release.
“People who have consumed only alcohol, who feel tired and intoxicated, may be more likely to acknowledge that they are drunk.” Gould tells Web MD in an email that "coffee may reduce the sedative effects of alcohol, which could give the false impression that people are not as intoxicated as they really are." But caffeine’s effect as a stimulant may create the illusion in intoxicated people that they are alert and competent enough “to handle potentially harmful situations, such as driving while intoxicated or placing themselves in dangerous social situations,” Gould says.
The journey only came to an end when she smashed into the back of a large van parked directly in front of her - causing her car to roll over and the airbags to deploy.
Liverpool Crown Court heard residents rushed to her aid and called police after finding her disorientated and smelling of alcohol.
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